Overdose

High doses can cause temporary confusion, upset concentration, or transitional visual hallucinations. Excessive dose can cause drowsiness, hypothermia, tachycardia other anomalies and arrhythmic, such as the block of branch of packet, the obviousness of ECG of weak, congestive conduction the heart failure, riot of motility ocular, convulsions, strict low blood pressure, stupour, coma, polyradiculoneuropathy and constipation. Other symptoms can be agitation, hyperactive reflexes, rigidity of muscle, vomiting, hyperpyrexia, or whatever of the listing under Adverse effects.

Treatment

All patients suspected of having taken an excessive dose should be accepted in a hospital as soon as possible. The treatment is symptomatic and all-helping. Empty so quickly stomach as possible by emesis coherent by gastric washing on the arrival in the hospital. Further to gastric washing, the charcoal speeded up can be managed. ECG should be taken and fact to watch near cardiac function instituted if there is a sign of anomaly. Support an opened airline and an adequate liquid consumption; regulate the temperature of body.

They announce that the intravenous administration of 1-3 mgs of physostigmine salicylate reverses the symptoms of poisoning of antidepressant tricyclic. Since physostigmine is fast transformed by metabolism, the proportion of physostigmine should be repeated as demanded particularly if the signs of threat of life such as arrhythmias, convulsions and deep coma reproduce or keep after the initial proportion of physostigmine. Since physostigmine it can itself be toxic, is not recommended for the use of routine.

Anticonvulsants can be given to control convulsions. Amitriptyline augments dépresseuse CNS action, but the action anticonvulsant of barbiturates; therefore, an anaesthetic of inhalation, diazepam, or paraldehyde is recommended for the control of convulsions.

As excessive dose is often deliberate, the patients can try the suicide by other means during the stage of recovery. The dead by deliberate or accidental excessive dose occurred with this class of medicaments.